Ozone as an adjunct to conventional nonsurgical therapy in chronic periodontitis: a randomized controlled clinical trial

• Published in: Journal of periodontal research 2015-02, Vol.50 (1), p.37-43
• Main Authors: Al Habashneh, R., Alsalman, W., Khader, Y.
• Format: Article
• Language: English
• Subjects: Adult; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - therapeutic use; antimicrobial; C-Reactive Protein - analysis; Chronic Periodontitis - therapy; Combined Modality Therapy; dental plaque; Dental Plaque Index; Dental Scaling - methods; Dentistry; Female; Follow-Up Studies; gingival index; Gingival Recession - classification; Gingival Recession - therapy; Humans; imflammatory mediator; Male; Middle Aged; Ozone - administration & dosage; Ozone - therapeutic use; Periodontal Attachment Loss - classification; Periodontal Attachment Loss - therapy; Periodontal Index; Periodontal Pocket - classification; Periodontal Pocket - therapy; periodontitis; Root Planing - methods; Therapeutic Irrigation - methods; treatment; Young Adult
• ISSN: 0022-3484; 1600-0765
• DOI: 10.1111/jre.12177

Background and Objective Currently, only limited data are available from controlled clinical trials regarding the effect of irrigation by ozonated water in the treatment of periodontitis. The aim of the present study was to determine the clinical and biological effects of the adjunctive use of ozone in nonsurgical periodontal treatment. Material and Methods Forty‐one patients with chronic periodontitis were randomized to treatment with either subgingival scaling and root planing (SRP) followed by irrigation with ozonated water (test) or subgingival SRP followed by irrigation with distilled water irrigation (control). The following parameters were evaluated at baseline (T0), 3 mo (T1): plaque index; gingival index; bleeding on probing; probing pocket depth; gingival recession; and clinical attachment loss. In addition, the serum concentrations of high sensitivity C‐reactive protein were measured at T0 and T1. Results Forty‐one patients with chronic periodontitis were included in the analysis (20 in the test group and 21 in the control group). There was statistically significant improvement in the study parameters in both groups between T0 and T1, except for gingival index. However, there were no significant differences in any study parameter between test and control groups. Conclusion Irrigation with ozonated water as an adjunctive therapy to SRP produces no statistically significant benefit compared with SRP plus distilled water irrigation.