Napsin A is a specific marker for ovarian clear cell adenocarcinoma

Ovarian clear cell adenocarcinoma has a relatively poor prognosis among the ovarian cancer subtypes because of its high chemoresistance. Differential diagnosis of clear cell adenocarcinoma from other ovarian surface epithelial tumors is important for its treatment. Napsin A is a known diagnostic mar...

Full description

Saved in:
Bibliographic Details
Published in:Modern pathology 2015-01, Vol.28 (1), p.111-117
Main Authors: Yamashita, Yoriko, Nagasaka, Tetsuro, Naiki-Ito, Aya, Sato, Shinya, Suzuki, Shugo, Toyokuni, Shinya, Ito, Masafumi, Takahashi, Satoru
Format: Article
Language:English
Subjects:
692/699/67/1517/1709
692/699/67/1857
692/700/139
Adenocarcinoma, Clear Cell - diagnosis
Adult
Aged
Aged, 80 and over
Aspartic Acid Endopeptidases - analysis
Aspartic Acid Endopeptidases - biosynthesis
Biomarkers, Tumor - analysis
clear cell adenofibroma
Female
Humans
Immunohistochemistry
Laboratory Medicine
Medicine
Medicine & Public Health
Middle Aged
napsin A
original-article
ovarian clear cell adenocarcinoma
Ovarian Neoplasms - diagnosis
Pathology
Sensitivity and Specificity
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ovarian clear cell adenocarcinoma has a relatively poor prognosis among the ovarian cancer subtypes because of its high chemoresistance. Differential diagnosis of clear cell adenocarcinoma from other ovarian surface epithelial tumors is important for its treatment. Napsin A is a known diagnostic marker for lung adenocarcinoma, and expression of napsin A is reported in a certain portion of thyroid and renal carcinomas. However, napsin A expression in ovarian surface epithelial tumors has not previously been examined. In this study, immunohistochemical analysis revealed that in 71 of 86 ovarian clear cell adenocarcinoma patients (83%) and all of the 13 patients with ovarian clear cell adenofibroma, positive napsin A staining was evident. No expression was observed in 30 serous adenocarcinomas, 11 serous adenomas or borderline tumors, 19 endometrioid adenocarcinomas, 22 mucinous adenomas or borderline tumors, 10 mucinous adenocarcinomas, or 3 yolk sac tumors of the ovary. Furthermore, expression of napsin A was not observed in the normal surface epithelium of the ovary, epithelia of the fallopian tubes, squamous epithelium, endocervical epithelium, or the endometrium of the uterus. Therefore, we propose that napsin A is another sensitive and specific marker for distinguishing ovarian clear cell tumors (especially adenocarcinomas) from other ovarian tumors.
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.2014.61