Natriuretic peptide in patients with Chagas disease: diagnostic utility in heart failure

The assessment of the type-B natriuretic peptide (BNP) has shown utility as a diagnostic and prognostic tool of heart failure. The aim of this study was to evaluate the BNP levels and to know its association within the systolic dysfunction level on Chagas disease. During the period 2010-2011, 64 pat...

Full description

Saved in:
Bibliographic Details
Published in:Investigación clínica 2014-12, Vol.55 (4), p.321-331
Main Authors: Pozo-Pérez, Arleth, Jorquera-Fernández, Alicia, Rodríguez-Urbaneja, Fernando, Romero-Peña, Leomery, Geraldino-Carvajal, Oscar, Cáceres-Cauro, Alfonso, Rosas-Martínez, María
Format: Article
Language:Spanish
Subjects:
Aged
Antibodies, Protozoan - blood
Biomarkers
Chagas Cardiomyopathy - blood
Chagas Cardiomyopathy - diagnosis
Chagas Cardiomyopathy - diagnostic imaging
Electrocardiography
Female
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure - diagnostic imaging
Heart Failure - etiology
Heart Failure - physiopathology
Humans
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Prognosis
ROC Curve
Sensitivity and Specificity
Severity of Illness Index
Trypanosoma cruzi - immunology
Ultrasonography
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - etiology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The assessment of the type-B natriuretic peptide (BNP) has shown utility as a diagnostic and prognostic tool of heart failure. The aim of this study was to evaluate the BNP levels and to know its association within the systolic dysfunction level on Chagas disease. During the period 2010-2011, 64 patients were evaluated in the Chagas clinic of the Cardiopulmonary Unit of the University Hospital Dr. Luis Razetti, Barcelona-Anzoátegui state, Venezuela. After confirming the seropositive state to antibodies anti-T. cruzi with three inmunoserological tests (ELISA, indirect inmunofluorescence and indirect hemaglutination), patients were classified into Groups I, II and III of cardiac disease, by the evaluation with electrocardiogram, echocardiogram and thorax radiography. Thirty three seronegative cardiological patients and eight healthy volunteers were included in the study as controls. BNP groups levels were as follow: Chagas I = 18.87 +/- 18.00 pg/mL (n=20), Chagas II = 99.88 +/- 171.52 pg/mL (n=24) y Chagas III = 365.80 +/- 280.54 pg/mL (n=20). The sensitivity and specificity of BNP were 85.0% and 93.2%, respectively, (p
ISSN:0535-5133