Effect of sleep deprivation on the growth hormone response to the alpha-2 adrenergic receptor agonist, clonidine, in normal subjects

One night's sleep deprivation (SD) increased the growth hormone (GH) response to clonidine (2 ug/kg iv) in 11 normal men (p < 0.005). This finding may indicate that SD enhances alpha-2 adrenergic receptor function or that the GH response to GH releasing factor is increased by SD.

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Bibliographic Details
Published in:Journal of Neural Transmission 1997-01, Vol.104 (2-3), p.291-298
Main Authors: LAL, S, THAVUNDAYIL, J. X, KRISHNAN, B, NAIR, N. P. V, SCHWARTZ, G, KIELY, M. E, GUYDA, H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Sleep. Vigilance
Vertebrates: nervous system and sense organs
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Description
Summary:One night's sleep deprivation (SD) increased the growth hormone (GH) response to clonidine (2 ug/kg iv) in 11 normal men (p < 0.005). This finding may indicate that SD enhances alpha-2 adrenergic receptor function or that the GH response to GH releasing factor is increased by SD.
ISSN:0300-9564
1435-1463
DOI:10.1007/BF01273189