Stimulation of erythromycin A yield by integration of a chromosomal DNA fragment including the eryC1 gene into the chromosome of Saccharopolyspora erythraea

A 5.2 kbp chromosomal DNA fragment including the eryC1 gene was integrated along with vector DNA into the chromosome of a S. erythraea wild-type strain. The erythromycin A production of transformants in the presence of thiostrepton was two to three times higher in comparison with the non-transformed...

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Bibliographic Details
Published in:Biotechnology letters 1993-02, Vol.15 (2), p.105-110
Main Authors: HÄNEL, F, SCHUMANN, G, FIEDLER, G, KRÜGEL, H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Genetic engineering
Genetic technics
Methods. Procedures. Technologies
Modification of gene expression level
Saccharopolyspora erythraea
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Summary:A 5.2 kbp chromosomal DNA fragment including the eryC1 gene was integrated along with vector DNA into the chromosome of a S. erythraea wild-type strain. The erythromycin A production of transformants in the presence of thiostrepton was two to three times higher in comparison with the non-transformed wild-type strain.
ISSN:0141-5492
1573-6776
DOI:10.1007/BF00133007