A new class of high affinity ligands for the neurokinin A NK sub(2) receptor: psi (CH sub(2)NR) reduced peptide bond analogues of neurokinin A sub(4-10)

Analogues of (Leu super(10))NKA sub(4-10) were synthesized in which each of the amide bonds was sequentially replaced with the reduced amide psi (CH sub(2)NH) bond to determine the effect of this structural modification on the antagonism of NKA binding to the HUB NK sub(2) receptor.

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Bibliographic Details
Published in:Journal of medicinal chemistry 1992-01, Vol.35 (21), p.3949-3955
Main Authors: Harbeson, S L, Shatzer, SA, Le, Tieu-Binh, Buck, SH
Format: Article
Language:English
Subjects:
analogs
ligands
neurokinin A
peptide bonds
peptide synthesis
receptors
Online Access:Get full text
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Description
Summary:Analogues of (Leu super(10))NKA sub(4-10) were synthesized in which each of the amide bonds was sequentially replaced with the reduced amide psi (CH sub(2)NH) bond to determine the effect of this structural modification on the antagonism of NKA binding to the HUB NK sub(2) receptor.
ISSN:0022-2623