A new class of high affinity ligands for the neurokinin A NK sub(2) receptor: psi (CH sub(2)NR) reduced peptide bond analogues of neurokinin A sub(4-10)

Analogues of (Leu super(10))NKA sub(4-10) were synthesized in which each of the amide bonds was sequentially replaced with the reduced amide psi (CH sub(2)NH) bond to determine the effect of this structural modification on the antagonism of NKA binding to the HUB NK sub(2) receptor.

Saved in:
Bibliographic Details
Published in:Journal of medicinal chemistry 1992-01, Vol.35 (21), p.3949-3955
Main Authors: Harbeson, S L, Shatzer, SA, Le, Tieu-Binh, Buck, SH
Format: Article
Language:English
Subjects:
analogs
ligands
neurokinin A
peptide bonds
peptide synthesis
receptors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 3955
container_issue 21
container_start_page 3949
container_title Journal of medicinal chemistry
container_volume 35
creator Harbeson, S L
Shatzer, SA
Le, Tieu-Binh
Buck, SH
description Analogues of (Leu super(10))NKA sub(4-10) were synthesized in which each of the amide bonds was sequentially replaced with the reduced amide psi (CH sub(2)NH) bond to determine the effect of this structural modification on the antagonism of NKA binding to the HUB NK sub(2) receptor.
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_16447332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16447332</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_164473323</originalsourceid><addsrcrecordid>eNqNjc1KAzEUhbNQaP15h7OSdjGQSYYK7kpRCkIX4r6kk5uZ1JiMuRPEN_FxnUo37lydxfedcy7EXEqlKrVSeiaumI9SSl0rPRffa0T6RBsMM5JD77sexjkf_fiF4DsTLcOljLGnSS05vU0sYo3dM7gcFmqJTC0NY8oPGNhjsdmewe7lxGxpyWKYDG8JhxQtTDQhdYV-L_-MnopNVcvljbh0JjDdnvNa3D09vm621ZDTx9Qc9--eWwrBREqF9_Wqae61Vvrf4g-h6VfR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16447332</pqid></control><display><type>article</type><title>A new class of high affinity ligands for the neurokinin A NK sub(2) receptor: psi (CH sub(2)NR) reduced peptide bond analogues of neurokinin A sub(4-10)</title><source>American Chemical Society</source><creator>Harbeson, S L ; Shatzer, SA ; Le, Tieu-Binh ; Buck, SH</creator><creatorcontrib>Harbeson, S L ; Shatzer, SA ; Le, Tieu-Binh ; Buck, SH</creatorcontrib><description>Analogues of (Leu super(10))NKA sub(4-10) were synthesized in which each of the amide bonds was sequentially replaced with the reduced amide psi (CH sub(2)NH) bond to determine the effect of this structural modification on the antagonism of NKA binding to the HUB NK sub(2) receptor.</description><identifier>ISSN: 0022-2623</identifier><language>eng</language><subject>analogs ; ligands ; neurokinin A ; peptide bonds ; peptide synthesis ; receptors</subject><ispartof>Journal of medicinal chemistry, 1992-01, Vol.35 (21), p.3949-3955</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Harbeson, S L</creatorcontrib><creatorcontrib>Shatzer, SA</creatorcontrib><creatorcontrib>Le, Tieu-Binh</creatorcontrib><creatorcontrib>Buck, SH</creatorcontrib><title>A new class of high affinity ligands for the neurokinin A NK sub(2) receptor: psi (CH sub(2)NR) reduced peptide bond analogues of neurokinin A sub(4-10)</title><title>Journal of medicinal chemistry</title><description>Analogues of (Leu super(10))NKA sub(4-10) were synthesized in which each of the amide bonds was sequentially replaced with the reduced amide psi (CH sub(2)NH) bond to determine the effect of this structural modification on the antagonism of NKA binding to the HUB NK sub(2) receptor.</description><subject>analogs</subject><subject>ligands</subject><subject>neurokinin A</subject><subject>peptide bonds</subject><subject>peptide synthesis</subject><subject>receptors</subject><issn>0022-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNqNjc1KAzEUhbNQaP15h7OSdjGQSYYK7kpRCkIX4r6kk5uZ1JiMuRPEN_FxnUo37lydxfedcy7EXEqlKrVSeiaumI9SSl0rPRffa0T6RBsMM5JD77sexjkf_fiF4DsTLcOljLGnSS05vU0sYo3dM7gcFmqJTC0NY8oPGNhjsdmewe7lxGxpyWKYDG8JhxQtTDQhdYV-L_-MnopNVcvljbh0JjDdnvNa3D09vm621ZDTx9Qc9--eWwrBREqF9_Wqae61Vvrf4g-h6VfR</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>Harbeson, S L</creator><creator>Shatzer, SA</creator><creator>Le, Tieu-Binh</creator><creator>Buck, SH</creator><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope></search><sort><creationdate>19920101</creationdate><title>A new class of high affinity ligands for the neurokinin A NK sub(2) receptor: psi (CH sub(2)NR) reduced peptide bond analogues of neurokinin A sub(4-10)</title><author>Harbeson, S L ; Shatzer, SA ; Le, Tieu-Binh ; Buck, SH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_164473323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>analogs</topic><topic>ligands</topic><topic>neurokinin A</topic><topic>peptide bonds</topic><topic>peptide synthesis</topic><topic>receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harbeson, S L</creatorcontrib><creatorcontrib>Shatzer, SA</creatorcontrib><creatorcontrib>Le, Tieu-Binh</creatorcontrib><creatorcontrib>Buck, SH</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harbeson, S L</au><au>Shatzer, SA</au><au>Le, Tieu-Binh</au><au>Buck, SH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new class of high affinity ligands for the neurokinin A NK sub(2) receptor: psi (CH sub(2)NR) reduced peptide bond analogues of neurokinin A sub(4-10)</atitle><jtitle>Journal of medicinal chemistry</jtitle><date>1992-01-01</date><risdate>1992</risdate><volume>35</volume><issue>21</issue><spage>3949</spage><epage>3955</epage><pages>3949-3955</pages><issn>0022-2623</issn><abstract>Analogues of (Leu super(10))NKA sub(4-10) were synthesized in which each of the amide bonds was sequentially replaced with the reduced amide psi (CH sub(2)NH) bond to determine the effect of this structural modification on the antagonism of NKA binding to the HUB NK sub(2) receptor.</abstract></addata></record>
fulltext fulltext
identifier ISSN: 0022-2623
ispartof Journal of medicinal chemistry, 1992-01, Vol.35 (21), p.3949-3955
issn 0022-2623
language eng
recordid cdi_proquest_miscellaneous_16447332
source American Chemical Society
subjects analogs
ligands
neurokinin A
peptide bonds
peptide synthesis
receptors
title A new class of high affinity ligands for the neurokinin A NK sub(2) receptor: psi (CH sub(2)NR) reduced peptide bond analogues of neurokinin A sub(4-10)
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T22%3A01%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20new%20class%20of%20high%20affinity%20ligands%20for%20the%20neurokinin%20A%20NK%20sub(2)%20receptor:%20psi%20(CH%20sub(2)NR)%20reduced%20peptide%20bond%20analogues%20of%20neurokinin%20A%20sub(4-10)&rft.jtitle=Journal%20of%20medicinal%20chemistry&rft.au=Harbeson,%20S%20L&rft.date=1992-01-01&rft.volume=35&rft.issue=21&rft.spage=3949&rft.epage=3955&rft.pages=3949-3955&rft.issn=0022-2623&rft_id=info:doi/&rft_dat=%3Cproquest%3E16447332%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_miscellaneous_164473323%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=16447332&rft_id=info:pmid/&rfr_iscdi=true