Serum H-FABP levels in patients with hypothyroidism

Summary Objective Hypothyroidism (HT) has an increased risk for cardiovascular mortality and morbidity due to increased atherosclerosis. Heart-type fatty acid binding protein (H-FABP) is abundant in the cytosol of cardiomyocytes, and transports fatty acids into these cells. Although H-FABP has been...

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Bibliographic Details
Published in:Wiener Klinische Wochenschrift 2014-11, Vol.126 (21-22), p.727-733
Main Authors: Gunes, Fahri, Asik, Mehmet, Temiz, Ahmet, Vural, Ahmet, Sen, Hacer, Binnetoglu, Emine, Bozkurt, Neslihan, Tekeli, Zeliha, Erbag, Gokhan, Ukinc, Kubilay, Akbal, Erdem
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis - blood
Atherosclerosis - diagnosis
Atherosclerosis - etiology
Biomarkers - blood
Endocrinology
Fatty Acid Binding Protein 3
Fatty Acid-Binding Proteins - blood
Female
Gastroenterology
Humans
Hypothyroidism - blood
Hypothyroidism - complications
Hypothyroidism - diagnosis
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Pneumology/Respiratory System
Reproducibility of Results
Risk Assessment
Sensitivity and Specificity
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Summary:Summary Objective Hypothyroidism (HT) has an increased risk for cardiovascular mortality and morbidity due to increased atherosclerosis. Heart-type fatty acid binding protein (H-FABP) is abundant in the cytosol of cardiomyocytes, and transports fatty acids into these cells. Although H-FABP has been shown to increase in several atherosclerotic and inflammatory conditions, there is no literature data indicating an alteration in other atherosclerotic processes such as HT. Material and methods A total of 39 patients with subclinical hypothyroidism (SCH), 26 patients with overt hypothyroidism (OH), and 29 healthy subjects were enrolled in this study. Carotid artery intima media thickness (CIMT) was measured by high resolution B mode ultrasonography. H-FABP levels, thyroid function test, and biochemical tests of all subjects were measured. The associations between H-FABP and thyroid test and CIMT were examined with correlation and regression analysis. Results OH patients had higher H-FABP levels (mean, 6.18 ± 3.08 ng/mL) than both the SCH (mean, 3.81 ± 2.16 ng/mL) and the controls (mean, 2.12 ± 1.27 ng/mL) ( P  
ISSN:0043-5325
1613-7671
DOI:10.1007/s00508-014-0612-7