Role of intraoral color Doppler sonography in predicting delayed cervical lymph node metastasis in patients with early-stage tongue cancer: a pilot study

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2015-02, Vol.119 (2), p.246-253
• Main Authors: Ariji, Yoshiko, DDS, PhD, Goto, Mitsuo, DDS, PhD, Fukano, Hideo, DDS, PhD, Sugita, Yoshihiko, DDS, PhD, Izumi, Masahiro, DDS, PhD, Ariji, Eiichiro, DDS, PhD
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - diagnostic imaging; Carcinoma, Squamous Cell - pathology; Dentistry; Female; Humans; Lymphatic Metastasis - diagnostic imaging; Lymphatic Metastasis - pathology; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Pilot Projects; Surgery; Tongue Neoplasms - diagnostic imaging; Tongue Neoplasms - pathology; Ultrasonography, Doppler, Color - instrumentation
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2014.10.021

Objective To clarify the intraoral color Doppler sonographic features of tongue cancer in relation to cervical lymph node metastasis. Study Design Thirty-one patients (24 men and 7 women; 32-87 years old; median 60.6 years) with T1-2 N0 squamous cell carcinoma of the tongue were enrolled. Preoperative clinical information and sonographic findings were collected. Patients were followed up for 2 years or more, and the presence of delayed lymph node metastasis was investigated. Significant clinical and sonographic factors were evaluated in relation to lymph node metastasis. Results Significant differences in maximum and minimum tumor size, clinical type, tumor depth and thickness, shape of the invading front of the tumor, vascular index (VI) of the tumor area, and asymmetry of the VI of the deep lingual artery were observed between patients with cervical lymph node metastasis and those without. The areas under the curve (AUCs) of tumor thickness and the VI of the tumor area were 0.861 and 0.909, respectively, on receiver operating characteristic (ROC) curve analysis for predicting lymph node metastasis. The AUC for the VI showed a slightly higher value, although the difference was not significant ( P  = .532). Conclusions Intraoral color Doppler sonography is recommended, as it may identify predictive factors of cervical lymph node metastasis.