A meta-analysis of cognitive functions in children and adolescents with major depressive disorder

The cumulative prevalence rates of major depressive disorders (MDD) in children and adolescents averages 9.5 %. The majority of adults with MDD suffer from significant cognitive deficits, but the available neuropsychological data on the cognitive performance of children and adolescents with MDD yiel...

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Bibliographic Details
Published in:European child & adolescent psychiatry 2015-01, Vol.24 (1), p.5-19
Main Authors: Wagner, Stefanie, Müller, Carmen, Helmreich, Isabella, Huss, Michael, Tadić, André
Format: Article
Language:English
Subjects:
Adolescent
Case-Control Studies
Child
Child and Adolescent Psychiatry
Cognition - physiology
Cognition Disorders - physiopathology
Depressive Disorder, Major - physiopathology
Depressive Disorder, Major - psychology
Humans
Medicine
Medicine & Public Health
Neuropsychological Tests
Psychiatry
Review
Systematic review
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Summary:The cumulative prevalence rates of major depressive disorders (MDD) in children and adolescents averages 9.5 %. The majority of adults with MDD suffer from significant cognitive deficits, but the available neuropsychological data on the cognitive performance of children and adolescents with MDD yielded mixed results. Meta-analytic methods were used to assess the severity of cognitive deficits in children and adolescents with MDD as compared to healthy children and adolescents. We identified 17 studies comparing the intelligence, executive functions, verbal memory and attention of 447 patients with DSM-IV MDD and 1,347 healthy children and adolescents. Children and adolescents with MDD performed 0.194–0.772 ( p  
ISSN:1018-8827
1435-165X
DOI:10.1007/s00787-014-0559-2