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Homeobox Gene Prx3 Expression in Rodent Brain and Extraneural Tissues
Different cDNA clones encoding a rat homeobox gene and the mouse homologue OG-12 were cloned from adult rat brain and mouse embryo mRNA, respectively. The predicted amino acid sequences of the proteins belong to the paired-related subfamily of homeodomain proteins (Prx homeodomains). Hence, the gene...
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Published in: | Proceedings of the National Academy of Sciences - PNAS 1997-11, Vol.94 (24), p.12993-12998 |
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creator | Hermien S. A. Van Schaick Smidt, Marten P. Rovescalli, Alessandra Cecilia Luijten, Mirjam Arno A. M. Van Der Kleij Asoh, Sadamitsu Kozak, Christine A. Nirenberg, Marshall Burbach, Peter H. |
description | Different cDNA clones encoding a rat homeobox gene and the mouse homologue OG-12 were cloned from adult rat brain and mouse embryo mRNA, respectively. The predicted amino acid sequences of the proteins belong to the paired-related subfamily of homeodomain proteins (Prx homeodomains). Hence, the gene was named Prx3 and the mouse and rat genes are indicated as mPrx3 and rPrx3, respectively. In the mouse as well as in the rat, the predicted Prx3 proteins share the homeodomain but have three different N termini, a 12-aa residue variation in the C terminus, and contain a 14-aa residue motif common to a subset of homeodomain proteins, termed the ``aristaless domain.'' Genetic mapping of Prx3 in the mouse placed this gene on chromosome 3. In situ hybridization on whole mount 12.5-day-old mouse embryos and sections of rat embryos at 14.5 and 16.5 days postcoitum revealed marked neural expression in discrete regions in the lateral and medial geniculate complex, superior and inferior colliculus, the superficial gray layer of the superior colliculus, pontine reticular formation, and inferior olive. In rat and mouse embryos, nonneuronal structures around the oral cavity and in hip and shoulder regions also expressed the Prx3 gene. In the adult rat brain, Prx3 gene expression was restricted to thalamic, tectal, and brainstem structures that include relay nuclei of the visual and auditory systems as well as other ascending systems conveying somatosensory information. Prx3 may have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. |
doi_str_mv | 10.1073/pnas.94.24.12993 |
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A. Van Schaick ; Smidt, Marten P. ; Rovescalli, Alessandra Cecilia ; Luijten, Mirjam ; Arno A. M. Van Der Kleij ; Asoh, Sadamitsu ; Kozak, Christine A. ; Nirenberg, Marshall ; Burbach, Peter H.</creator><creatorcontrib>Hermien S. A. Van Schaick ; Smidt, Marten P. ; Rovescalli, Alessandra Cecilia ; Luijten, Mirjam ; Arno A. M. Van Der Kleij ; Asoh, Sadamitsu ; Kozak, Christine A. ; Nirenberg, Marshall ; Burbach, Peter H.</creatorcontrib><description>Different cDNA clones encoding a rat homeobox gene and the mouse homologue OG-12 were cloned from adult rat brain and mouse embryo mRNA, respectively. The predicted amino acid sequences of the proteins belong to the paired-related subfamily of homeodomain proteins (Prx homeodomains). Hence, the gene was named Prx3 and the mouse and rat genes are indicated as mPrx3 and rPrx3, respectively. In the mouse as well as in the rat, the predicted Prx3 proteins share the homeodomain but have three different N termini, a 12-aa residue variation in the C terminus, and contain a 14-aa residue motif common to a subset of homeodomain proteins, termed the ``aristaless domain.'' Genetic mapping of Prx3 in the mouse placed this gene on chromosome 3. In situ hybridization on whole mount 12.5-day-old mouse embryos and sections of rat embryos at 14.5 and 16.5 days postcoitum revealed marked neural expression in discrete regions in the lateral and medial geniculate complex, superior and inferior colliculus, the superficial gray layer of the superior colliculus, pontine reticular formation, and inferior olive. In rat and mouse embryos, nonneuronal structures around the oral cavity and in hip and shoulder regions also expressed the Prx3 gene. In the adult rat brain, Prx3 gene expression was restricted to thalamic, tectal, and brainstem structures that include relay nuclei of the visual and auditory systems as well as other ascending systems conveying somatosensory information. Prx3 may have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.94.24.12993</identifier><identifier>PMID: 9371788</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Amino Acid Sequence ; Amino acids ; Animals ; Base Sequence ; Biological Sciences ; Brain ; Brain - metabolism ; Chromosome Mapping ; Cloning, Molecular ; Complementary DNA ; DNA ; DNA, Complementary ; Embryonic and Fetal Development - genetics ; Embryos ; Gene Expression Regulation, Developmental ; Genes ; Genes, Homeobox ; Homeobox genes ; Homeodomain proteins ; Homeodomain Proteins - genetics ; In situ hybridization ; Mice ; Molecular Sequence Data ; Nervous system ; Proteins ; Rats ; Rodents ; Zoology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1997-11, Vol.94 (24), p.12993-12998</ispartof><rights>Copyright 1993-1997 National Academy of Sciences</rights><rights>Copyright National Academy of Sciences Nov 25, 1997</rights><rights>Copyright © 1997, The National Academy of Sciences of the USA 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/94/24.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/43529$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/43529$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9371788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hermien S. A. Van Schaick</creatorcontrib><creatorcontrib>Smidt, Marten P.</creatorcontrib><creatorcontrib>Rovescalli, Alessandra Cecilia</creatorcontrib><creatorcontrib>Luijten, Mirjam</creatorcontrib><creatorcontrib>Arno A. M. Van Der Kleij</creatorcontrib><creatorcontrib>Asoh, Sadamitsu</creatorcontrib><creatorcontrib>Kozak, Christine A.</creatorcontrib><creatorcontrib>Nirenberg, Marshall</creatorcontrib><creatorcontrib>Burbach, Peter H.</creatorcontrib><title>Homeobox Gene Prx3 Expression in Rodent Brain and Extraneural Tissues</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Different cDNA clones encoding a rat homeobox gene and the mouse homologue OG-12 were cloned from adult rat brain and mouse embryo mRNA, respectively. The predicted amino acid sequences of the proteins belong to the paired-related subfamily of homeodomain proteins (Prx homeodomains). 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In the adult rat brain, Prx3 gene expression was restricted to thalamic, tectal, and brainstem structures that include relay nuclei of the visual and auditory systems as well as other ascending systems conveying somatosensory information. Prx3 may have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological Sciences</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Chromosome Mapping</subject><subject>Cloning, Molecular</subject><subject>Complementary DNA</subject><subject>DNA</subject><subject>DNA, Complementary</subject><subject>Embryonic and Fetal Development - genetics</subject><subject>Embryos</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes</subject><subject>Genes, Homeobox</subject><subject>Homeobox genes</subject><subject>Homeodomain proteins</subject><subject>Homeodomain Proteins - genetics</subject><subject>In situ hybridization</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Nervous system</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rodents</subject><subject>Zoology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkUtLxDAURoMoOo7uRRCLC3HTMTdJmwbcqIwPEBTRdUjaVDt0kjFpZfz3Rh18LTSbEL6Te09yEdoCPALM6eHMqjASbETYCIgQdAkNAAtIcybwMhpgTHhaMMLW0HoIE4yxyAq8ilYF5cCLYoDGF25qnHbz5NxYk9z4OU3G85k3ITTOJo1Nbl1lbJeceBUPylYx7ryypveqTe6aEHoTNtBKrdpgNhf7EN2fje9OL9Kr6_PL0-OrdEIF7VLIgApmSlpVzAAnGYFcgSgLrSgUoDErNS11XVdC87gMz8tS8yzXRgnOazpERx91Z72emqqMYtFCznwzVf5FOtXIn4ltHuWDe5aEkdh7iPYX1717itqdnDahNG0bn-P6ILlgGQNM_wUhZxkF9gbu_QInrvc2_oEkGGiG8_dqO9-tP3UXQ4j5wSKP0_xKWbSW71OVdd-2nZl3Ed39G43E9gcxCZ3znwijGRH0FQq_qtk</recordid><startdate>19971125</startdate><enddate>19971125</enddate><creator>Hermien S. A. Van Schaick</creator><creator>Smidt, Marten P.</creator><creator>Rovescalli, Alessandra Cecilia</creator><creator>Luijten, Mirjam</creator><creator>Arno A. M. Van Der Kleij</creator><creator>Asoh, Sadamitsu</creator><creator>Kozak, Christine A.</creator><creator>Nirenberg, Marshall</creator><creator>Burbach, Peter H.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><general>The National Academy of Sciences of the USA</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19971125</creationdate><title>Homeobox Gene Prx3 Expression in Rodent Brain and Extraneural Tissues</title><author>Hermien S. A. Van Schaick ; Smidt, Marten P. ; Rovescalli, Alessandra Cecilia ; Luijten, Mirjam ; Arno A. M. 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A. Van Schaick</au><au>Smidt, Marten P.</au><au>Rovescalli, Alessandra Cecilia</au><au>Luijten, Mirjam</au><au>Arno A. M. Van Der Kleij</au><au>Asoh, Sadamitsu</au><au>Kozak, Christine A.</au><au>Nirenberg, Marshall</au><au>Burbach, Peter H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homeobox Gene Prx3 Expression in Rodent Brain and Extraneural Tissues</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1997-11-25</date><risdate>1997</risdate><volume>94</volume><issue>24</issue><spage>12993</spage><epage>12998</epage><pages>12993-12998</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Different cDNA clones encoding a rat homeobox gene and the mouse homologue OG-12 were cloned from adult rat brain and mouse embryo mRNA, respectively. The predicted amino acid sequences of the proteins belong to the paired-related subfamily of homeodomain proteins (Prx homeodomains). Hence, the gene was named Prx3 and the mouse and rat genes are indicated as mPrx3 and rPrx3, respectively. In the mouse as well as in the rat, the predicted Prx3 proteins share the homeodomain but have three different N termini, a 12-aa residue variation in the C terminus, and contain a 14-aa residue motif common to a subset of homeodomain proteins, termed the ``aristaless domain.'' Genetic mapping of Prx3 in the mouse placed this gene on chromosome 3. In situ hybridization on whole mount 12.5-day-old mouse embryos and sections of rat embryos at 14.5 and 16.5 days postcoitum revealed marked neural expression in discrete regions in the lateral and medial geniculate complex, superior and inferior colliculus, the superficial gray layer of the superior colliculus, pontine reticular formation, and inferior olive. In rat and mouse embryos, nonneuronal structures around the oral cavity and in hip and shoulder regions also expressed the Prx3 gene. In the adult rat brain, Prx3 gene expression was restricted to thalamic, tectal, and brainstem structures that include relay nuclei of the visual and auditory systems as well as other ascending systems conveying somatosensory information. Prx3 may have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>9371788</pmid><doi>10.1073/pnas.94.24.12993</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Amino Acid Sequence Amino acids Animals Base Sequence Biological Sciences Brain Brain - metabolism Chromosome Mapping Cloning, Molecular Complementary DNA DNA DNA, Complementary Embryonic and Fetal Development - genetics Embryos Gene Expression Regulation, Developmental Genes Genes, Homeobox Homeobox genes Homeodomain proteins Homeodomain Proteins - genetics In situ hybridization Mice Molecular Sequence Data Nervous system Proteins Rats Rodents Zoology |
title | Homeobox Gene Prx3 Expression in Rodent Brain and Extraneural Tissues |
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