Effect of p21 super(WAF1/CIP1) Expression on Tumor Progression in Bladder Cancer

Altered expression of p53 protein is an important predictor of progression in bladder cancer. The action of p53 on cell cycle regulation is mediated, in part, through expression of the cyclin-dependent kinase inhibitor p21 super(WAF1/CIP1) (p21). Loss of p21 expression may, therefore, contribute to...

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Published in:JNCI : Journal of the National Cancer Institute 1998-07, Vol.90 (14), p.1072-1079
Main Authors: Stein, J P, Ginsberg, DA, Grossfeld, G D, Chatterjee, S J, Esrig, D, Dickinson, M G, Groshen, S, Taylor, C R, Jones, P A, Skinner, D G, Cote, R J
Format: Article
Language:English
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Summary:Altered expression of p53 protein is an important predictor of progression in bladder cancer. The action of p53 on cell cycle regulation is mediated, in part, through expression of the cyclin-dependent kinase inhibitor p21 super(WAF1/CIP1) (p21). Loss of p21 expression may, therefore, contribute to tumor progression. We sought to determine the relationship between p21 expression in bladder cancer and disease progression. Tumor specimens were obtained from 242 patients who underwent cystectomy for bladder cancer. Median follow-up was 8.5 years (range, 0.1-11.8 years). Nuclear p21 status was determined by immunohistochemistry and was then analyzed in relationship to the probability of tumor recurrence, overall survival, and tumor p53 status. Reported P values are two-sided. Nuclear p21 expression was detected in the tumors of 156 (64%) of the 242 patients. Patients with p21-positive tumors had a decreased probability of tumor recurrence (P
ISSN:0027-8874