Structures of the efrapeptins: potent inhibitors of mitochondrial ATPase from the fungus Tolypocladium niveum

The efrapeptins are a series of novel peptides produced by the entomopathogenic fungus Tolypocladium niveum . In addition to their insect toxicity, they strongly inhibit mitochondrial ATPase and photophosphorylation in chloroplasts. The efrapeptins probably act by binding competitively to the cataly...

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Bibliographic Details
Published in:Journal of the American Chemical Society 1991-01, Vol.113 (2), p.707-709
Main Authors: Gupta, Sandeep, Krasnoff, Stuart B., Roberts, Donald W., Renwick, J. A. A., Brinen, Linda S., Clardy, Jon
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Biological and medical sciences
efrapeptin
Fundamental and applied biological sciences. Psychology
H super(+)-transporting ATPase
inhibitors
mitochondria
Proteins
structure
Tolypocladium niveum
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Summary:The efrapeptins are a series of novel peptides produced by the entomopathogenic fungus Tolypocladium niveum . In addition to their insect toxicity, they strongly inhibit mitochondrial ATPase and photophosphorylation in chloroplasts. The efrapeptins probably act by binding competitively to the catalytic site of the soluble (F sub(1)) part of mitochondrial ATPase and blocking an essential arginine residue at the adenine nucleotide binding site.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja00002a068