Decrease in sigma but no increase in striatal dopamine D sub(4) sites in schizophrenic brains

[ super(3)H]Nemonapride differentially defines sigma and dopamine receptor sites depending upon assay conditions. In post-mortem schizophrenic brain tissues, [ super(3)H]nemonapride-labeled sigma receptor binding is decreased compared to matched normal controls. No striatal dopamine D sub(4)/D sub(4...

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Bibliographic Details
Published in:European journal of pharmacology 1996-10, Vol.314 (3), p.R3-R5
Main Authors: Helmeste, D M, Tang, Siu W, Bunney, WE Jr, Potkin, S G, Jones, E G
Format: Article
Language:English
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Summary:[ super(3)H]Nemonapride differentially defines sigma and dopamine receptor sites depending upon assay conditions. In post-mortem schizophrenic brain tissues, [ super(3)H]nemonapride-labeled sigma receptor binding is decreased compared to matched normal controls. No striatal dopamine D sub(4)/D sub(4)-like receptor differential was observed between the schizophrenic or control tissues, using the [ super(3)H]nemonapride minus [ super(3)H]raclopride subtraction method.
ISSN:0014-2999