Predictive Value of Admission Platelet Volume Indices for In-hospital Major Adverse Cardiovascular Events in Acute ST-Segment Elevation Myocardial Infarction

Although mean platelet volume (MPV) is an independent correlate of impaired angiographic reperfusion and 6-month mortality in ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI), there is less data regarding the association between platel...

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Bibliographic Details
Published in:Angiology 2015-02, Vol.66 (2), p.155-162
Main Authors: Celik, Turgay, Kaya, Mehmet G., Akpek, Mahmut, Gunebakmaz, Ozgur, Balta, Sevket, Sarli, Bahadir, Duran, Mustafa, Demirkol, Sait, Uysal, Onur Kadir, Oguzhan, Abdurrahman, Gibson, C. Michael
Format: Article
Language:English
Subjects:
Aged
Chi-Square Distribution
Coronary Angiography
Coronary Thrombosis - blood
Coronary Thrombosis - etiology
Coronary Thrombosis - mortality
Female
Hospital Mortality
Humans
Logistic Models
Male
Mean Platelet Volume
Middle Aged
Multivariate Analysis
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - mortality
Myocardial Infarction - therapy
No-Reflow Phenomenon - blood
No-Reflow Phenomenon - etiology
No-Reflow Phenomenon - mortality
Odds Ratio
Patient Admission
Percutaneous Coronary Intervention - adverse effects
Percutaneous Coronary Intervention - instrumentation
Percutaneous Coronary Intervention - mortality
Predictive Value of Tests
Recurrence
Risk Factors
Stents
Time Factors
Treatment Outcome
Turkey
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Summary:Although mean platelet volume (MPV) is an independent correlate of impaired angiographic reperfusion and 6-month mortality in ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI), there is less data regarding the association between platelet distribution width (PDW) and in-hospital major adverse cardiovascular events (MACEs). A total of 306 patients with STEMI pPCI were evaluated. No reflow was defined as a post-PCI thrombolysis in myocardial infarction (TIMI) flow grade of 0, 1, or 2 (group 1). Angiographic success was defined as TIMI flow grade 3 (group 2). The values of MPV and PDW were higher among patients with no reflow. In-stent thrombosis, nonfatal myocardial infarction, in-hospital mortality, and MACEs were significantly more frequent among patients with no reflow. In multivariate analysis, PDW, MPV, high-sensitivity C-reactive protein, and glucose on admission were independent correlates of in-hospital MACEs. Admission PDW and MPV are independent correlates of no reflow and in-hospital MACEs among patients with STEMI undergoing pPCI.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319713513493