Structure and hypolipidaemic activity of fucoidan extracted from brown seaweed Sargassum henslowianum

The aim of this study is to elucidate the structure and investigate the hypolipidaemic activity of a fucoidan extracted from brown seaweed Sargassum henslowianum collected at Hai Van-Son Cha peninsula, Hue province, Vietnam by using tandem electrospray ionisation mass spectrometry. The results demon...

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Bibliographic Details
Published in:Natural product research 2015-03, Vol.29 (5), p.411-415
Main Authors: Cuong, Ho Duc, Thuy, Thanh Thi Thu, Huong, Tran Thu, Ly, Bui Minh, Van, Tran Thi Thanh
Format: Article
Language:English
Subjects:
Animals
brown seaweed Sargassum henslowianum
Fucoidan
hypolipidaemic activity
Hypolipidemic Agents - chemistry
Hypolipidemic Agents - pharmacology
Mice, Inbred BALB C
Polysaccharides - chemistry
Polysaccharides - pharmacology
Sargassum - chemistry
Seaweed - chemistry
Spectrometry, Mass, Electrospray Ionization
structure
Vietnam
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Summary:The aim of this study is to elucidate the structure and investigate the hypolipidaemic activity of a fucoidan extracted from brown seaweed Sargassum henslowianum collected at Hai Van-Son Cha peninsula, Hue province, Vietnam by using tandem electrospray ionisation mass spectrometry. The results demonstrated that the fucoidan has α(1 → 3)-linked l-fucopyranose backbone and sulphate groups occupied mostly at C-2, C-4 and sometimes at C-3 position of fucose residues. The results of in vivo bioactivity examination revealed that the fucoidan in the dose of 100 mg/kgP/day by oral administration helped decrease cholesterol, triglyceride and LDL-cholesterol levels on obese mice.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2014.948436