Structure and hypolipidaemic activity of fucoidan extracted from brown seaweed Sargassum henslowianum

The aim of this study is to elucidate the structure and investigate the hypolipidaemic activity of a fucoidan extracted from brown seaweed Sargassum henslowianum collected at Hai Van-Son Cha peninsula, Hue province, Vietnam by using tandem electrospray ionisation mass spectrometry. The results demon...

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Published in:Natural product research 2015-03, Vol.29 (5), p.411-415
Main Authors: Cuong, Ho Duc, Thuy, Thanh Thi Thu, Huong, Tran Thu, Ly, Bui Minh, Van, Tran Thi Thanh
Format: Article
Language:English
Subjects:
Animals
brown seaweed Sargassum henslowianum
Fucoidan
hypolipidaemic activity
Hypolipidemic Agents - chemistry
Hypolipidemic Agents - pharmacology
Mice, Inbred BALB C
Polysaccharides - chemistry
Polysaccharides - pharmacology
Sargassum - chemistry
Seaweed - chemistry
Spectrometry, Mass, Electrospray Ionization
structure
Vietnam
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cited_by cdi_FETCH-LOGICAL-c433t-851a7452cabf8bdf98415ae7777ae32edcb8bb4b25d40e12263e6ecf03d1f9813
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container_title Natural product research
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creator Cuong, Ho Duc
Thuy, Thanh Thi Thu
Huong, Tran Thu
Ly, Bui Minh
Van, Tran Thi Thanh
description The aim of this study is to elucidate the structure and investigate the hypolipidaemic activity of a fucoidan extracted from brown seaweed Sargassum henslowianum collected at Hai Van-Son Cha peninsula, Hue province, Vietnam by using tandem electrospray ionisation mass spectrometry. The results demonstrated that the fucoidan has α(1 → 3)-linked l-fucopyranose backbone and sulphate groups occupied mostly at C-2, C-4 and sometimes at C-3 position of fucose residues. The results of in vivo bioactivity examination revealed that the fucoidan in the dose of 100 mg/kgP/day by oral administration helped decrease cholesterol, triglyceride and LDL-cholesterol levels on obese mice.
doi_str_mv 10.1080/14786419.2014.948436
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ispartof Natural product research, 2015-03, Vol.29 (5), p.411-415
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1478-6427
language eng
recordid cdi_proquest_miscellaneous_1645776270
source Taylor and Francis Science and Technology Collection
subjects Animals
brown seaweed Sargassum henslowianum
Fucoidan
hypolipidaemic activity
Hypolipidemic Agents - chemistry
Hypolipidemic Agents - pharmacology
Mice, Inbred BALB C
Polysaccharides - chemistry
Polysaccharides - pharmacology
Sargassum - chemistry
Seaweed - chemistry
Spectrometry, Mass, Electrospray Ionization
structure
Vietnam
title Structure and hypolipidaemic activity of fucoidan extracted from brown seaweed Sargassum henslowianum
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