Evidence for a Depressive-like State Induced by Repeated Saline Injections in Fischer 344 Rats

We investigated the behavioral changes induced by mild stress in animals that may be relatively susceptible to a depressive-like state, the Fischer 344 rat strain. The mild stress of repeated handling and intraperitoneal (IP) injections with saline (2 ml/kg, twice a day for 14 days) elicited a moder...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1997-08, Vol.57 (4), p.883-888
Main Authors: Izumi, Junkichi, Washizuka, Masataka, Hayashi-Kuwabara, Yu, Yoshinaga, Koji, Tanaka, Yoshiaki, Ikeda, Yugo, Kiuchi, Yuji, Oguchi, Katsuji
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents, Tricyclic - pharmacology
Biological and medical sciences
Body Weight
Depressive Disorder - chemically induced
Depressive Disorder - physiopathology
Depressive Disorder - psychology
Depressive state
Emotional animals
Emotions - physiology
Fischer 344 strain rats
Handling (Psychology)
Hindlimb Suspension
Imipramine
Imipramine - pharmacology
Male
Medical sciences
Mild stress
Motor Activity - physiology
Neuropharmacology
Open field behavior
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred F344
Rats, Sprague-Dawley
Repeated saline injections
Sodium Chloride - toxicity
Tail suspension test
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Summary:We investigated the behavioral changes induced by mild stress in animals that may be relatively susceptible to a depressive-like state, the Fischer 344 rat strain. The mild stress of repeated handling and intraperitoneal (IP) injections with saline (2 ml/kg, twice a day for 14 days) elicited a moderate suppression of body weight gain, a decrease in open field activity, and a prolonged immobility during the tail suspension test in Fischer 344 rats compared with Sprague–Dawley rats. Chronic treatment of Fischer 344 rats with imipramine (10 mg/kg IP, twice a day for 14 days) effectively suppressed open field activity and prolonged immobility. These results suggest that repeated saline injections may be a mild stressor in these rats. In the Fischer 344 strain, which may be vulnerable to the effects of mild stressors, repeated saline injections might induce a depressive-like state and could presumably represent an experimental model for depression.
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(96)00455-8