Evaluation of hepatotoxicity and clastogenicity of carbofuran in male Wistar rats

•Carbofuran pesticides have gained wide usage resulting in animals and human population’s exposure in their environment.•The present study examined the hepatoxicity and clastogenic effects of carbofuran in rats’ experimental model.•We found that carbofuran induced significant increase in the activit...

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Bibliographic Details
Published in:Food and chemical toxicology 2014-03, Vol.65, p.115-119
Main Authors: Gbadegesin, Michael A., Owumi, Solomon E., Akinseye, Victor, Odunola, Oyeronke A.
Format: Article
Language:English
Subjects:
Alanine aminotransferase
Animals
Biological and medical sciences
Carbamate
Carbofuran
Carbofuran - toxicity
Gamma gluthamyltransferase
Liver - drug effects
Male
Medical sciences
Micronucleated polychromatic erythrocytes (mPCEs)
Mutagens - toxicity
Pesticides, fertilizers and other agrochemicals toxicology
Rats
Rats, Wistar
Toxicology
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Summary:•Carbofuran pesticides have gained wide usage resulting in animals and human population’s exposure in their environment.•The present study examined the hepatoxicity and clastogenic effects of carbofuran in rats’ experimental model.•We found that carbofuran induced significant increase in the activity of serum enzymes indices of hepatotoxicity.•It also induced micronucleated polychromatic erythrocytes formation in the bone marrow as compared with the control.•Histology of liver samples from the treated groups revealed that the insecticide may hamper with liver cells integrity. Carbofuran based pesticides have gained wide usage in Nigeria recently. Consequently, animals and human populations are exposed to them in the environment. Information on in vivo toxicity of carbofuran in experimental models is scanty. The present study therefore examined the hepatotoxicity and clastogenic effects of carbofuran in rats. Male Wistar rats were exposed to carbofuran (p.o) at 0–5mg/kg bw for 5weeks. Carbofuran induced significant (p
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2013.12.034