Physical training prevents depressive symptoms and a decrease in brain-derived neurotrophic factor in Parkinson's disease

Highlights • We showed important changes in the behavior and neurochemical parameters induced by exercise in an experimental model of PD. • We showed that running and strength training have specific responses on the behavior and neurochemical parameters. • We showed that physical exercise modulates...

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Bibliographic Details
Published in:Brain research bulletin 2014-09, Vol.108, p.106-112
Main Authors: Tuon, T, Valvassori, S.S, Dal Pont, G.C, Paganini, C.S, Pozzi, B.G, Luciano, T.F, Souza, P.S, Quevedo, J, Souza, C.T, Pinho, R.A
Format: Article
Language:English
Subjects:
6-Hydroxydopamine
Animals
Brain-Derived Neurotrophic Factor - metabolism
Depression
Depression - etiology
Depression - metabolism
Depression - prevention & control
Disease Models, Animal
Exercise Therapy
Male
Mice
Mice, Inbred C57BL
Motor Activity
Neurology
Neurotrophins
Oxidopamine - toxicity
Parkinson Disease - complications
Parkinson Disease - metabolism
Parkinson's disease
Physical exercise
Receptor, trkB - metabolism
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Summary:Highlights • We showed important changes in the behavior and neurochemical parameters induced by exercise in an experimental model of PD. • We showed that running and strength training have specific responses on the behavior and neurochemical parameters. • We showed that physical exercise modulates pro-BDNF, BDNF, and TrkB in the striatum and hippocampus. • We showed that intensity of the effort is the most important factor to be considered when prescribing exercise.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2014.09.006