Effect of acute asenapine treatment on Fos expression in the forebrain structures under normal conditions and mild stress preconditioning in the rat

Highlights • Asenapine (ASE) is a novel atypical antipsychotic designated for treatment of schizophrenia. • ASE effect on Fos expression in striatum, septum, nucleus accumbens, and prefrontal cortex was studied. • ASE induced significant Fos expression almost in all the striatal structures analyzed....

Full description

Saved in:
Bibliographic Details
Published in:Brain research bulletin 2014-09, Vol.108, p.60-66
Main Authors: Majercikova, Zuzana, Cernackova, Alena, Horvathova, Lubica, Osacka, Jana, Pecenak, Jan, Kiss, Alexander
Format: Article
Language:English
Subjects:
Animals
Antipsychotic Agents - pharmacology
Asenapine
Chronic unpredictable variable mild stress (CMS)
Fos expression
Heterocyclic Compounds, 4 or More Rings - pharmacology
Male
Neurology
Neurons - drug effects
Neurons - metabolism
Prosencephalon - drug effects
Prosencephalon - metabolism
Proto-Oncogene Proteins c-fos - metabolism
Rat
Rats
Rats, Wistar
Stress, Psychological - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Asenapine (ASE) is a novel atypical antipsychotic designated for treatment of schizophrenia. • ASE effect on Fos expression in striatum, septum, nucleus accumbens, and prefrontal cortex was studied. • ASE induced significant Fos expression almost in all the striatal structures analyzed. • Chronic unpredictable variable mild stress lasting 21 days did not alter the impact of ASE.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2014.08.006