Fever-range whole-body heat treatment stimulates antigen-specific T-cell responses in humans

Highlights • We examined the effects of increase in core body temperature on the function of peripheral T cells in humans. • Enhanced cytokine production by T cells was induced by whole-body heat treatment. • Significant increase in membrane fluidity of T cells was induced by whole-body heat treatme...

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Bibliographic Details
Published in:Immunology letters 2014-11, Vol.162 (1), p.256-261
Main Authors: Kobayashi, Yasunobu, Ito, Yusuke, Ostapenko, Valentina V, Sakai, Mayuko, Matsushita, Norimasa, Imai, Kenichiro, Shimizu, Koichi, Aruga, Atsushi, Tanigawa, Keishi
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Antigens - immunology
Antigens - metabolism
Body Temperature
Cell Membrane - metabolism
Cytokines - biosynthesis
Hot Temperature
Humans
Hyperthermia
Hyperthermia, Induced
IFN-γ
IL-2
Interferon-gamma - biosynthesis
Male
Membrane Fluidity
Middle Aged
T cell
T-Cell Antigen Receptor Specificity - immunology
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
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Summary:Highlights • We examined the effects of increase in core body temperature on the function of peripheral T cells in humans. • Enhanced cytokine production by T cells was induced by whole-body heat treatment. • Significant increase in membrane fluidity of T cells was induced by whole-body heat treatment.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2014.09.014