Treg Cells and CTLA-4: The Ball and Chain of the Germinal Center Response

The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center. The mechanism by which re...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2014-12, Vol.41 (6), p.876-878
Main Authors: Linterman, Michelle A., Denton, Alice E.
Format: Article
Language:English
Subjects:
Animals
Antigens
B-Lymphocytes - immunology
Cell Proliferation
CTLA-4 Antigen - immunology
CTLA-4 Antigen - metabolism
Germinal Center - immunology
Immune system
Immunity, Humoral
Immunoglobulins
Infections
Ligands
Lymphocytes
Plasma
Proteins
Studies
T cell receptors
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Regulatory - immunology
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Description
Summary:The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center. The mechanism by which regulatory T cells control the germinal center response is unknown. Wing and colleagues and Sage and colleagues demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2014.12.009