On the brink: a new synaptic vesicle release model at the calyx of held

How vesicle calcium sensors interact with calcium channels at synapses affects neurotransmitter release dynamics. In this issue of Neuron, Nakamura et al. (2015) propose that synaptic vesicles are tightly coupled around the perimeter of a voltage-gated calcium channel cluster.

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2015-01, Vol.85 (1), p.6-8
Main Authors: Herman, Melissa A, Rosenmund, Christian
Format: Article
Language:English
Subjects:
Animals
Calcium - metabolism
Calcium channels
Calcium channels (voltage-gated)
Calcium Channels, N-Type - metabolism
Exocytosis - physiology
Medical imaging
Neurotransmitter release
Presynaptic Terminals - metabolism
Sensors
Synapses
Synapses - metabolism
Synaptic vesicles
Synaptic Vesicles - metabolism
Topography
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Description
Summary:How vesicle calcium sensors interact with calcium channels at synapses affects neurotransmitter release dynamics. In this issue of Neuron, Nakamura et al. (2015) propose that synaptic vesicles are tightly coupled around the perimeter of a voltage-gated calcium channel cluster.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2014.12.038