Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53 -deficient gpt delta mice

Highlights ► OTA raised Spi− mutant frequency in the kidneys of p53 -deficient gpt delta mice. ► OTA induced significant increase of p53 protein levels in the kidneys of mice. ► A lack of p53 elevated incidences of apoptosis and karyomegaly in renal tubules. ► OTA-induced phenomenon may arise from D...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2013-02, Vol.304, p.92-99
Main Authors: Hibi, Daisuke, Kijima, Aki, Suzuki, Yuta, Ishii, Yuji, Jin, Meilan, Sugita-Konishi, Yoshiko, Yanai, Tokuma, Nishikawa, Akiyoshi, Umemura, Takashi
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - drug effects
Blotting, Western
Carcinogens - administration & dosage
Carcinogens - toxicity
Deletion
Deltas
DNA Breaks, Double-Stranded - drug effects
DNA Damage - drug effects
Dose-Response Relationship, Drug
Emergency
Escherichia coli Proteins - genetics
Genes
Genes, p53 - genetics
Karyomegaly
Kidney - cytology
Kidney - drug effects
Kidney - pathology
Kidney Tubules - cytology
Kidney Tubules - drug effects
Kidney Tubules - pathology
Kidneys
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Mutagenicity
Mutagenicity Tests
Mutagens - administration & dosage
Mutagens - toxicity
Mutation
Mutations
Ochratoxin A
Ochratoxins - administration & dosage
Ochratoxins - toxicity
p53
Pentosyltransferases - genetics
Recombinational DNA Repair - drug effects
Repair
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Summary:Highlights ► OTA raised Spi− mutant frequency in the kidneys of p53 -deficient gpt delta mice. ► OTA induced significant increase of p53 protein levels in the kidneys of mice. ► A lack of p53 elevated incidences of apoptosis and karyomegaly in renal tubules. ► OTA-induced phenomenon may arise from DNA damage.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2012.12.005