Effect of Obesity on Acute Hemostatic Responses to Live-Fire Training Drills

The objective of this study was to evaluate the impact of obesity and firefighting activities on coagulation and fibrinolytic activity in relatively young, apparently healthy firefighters. Firefighters performed simulated firefighting activities for 18 minutes in a live-fire training structure. Bloo...

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Bibliographic Details
Published in:The American journal of cardiology 2014-12, Vol.114 (11), p.1768-1771
Main Authors: Smith, Denise L., PhD, Horn, Gavin P., PhD, Petruzzello, Steven J., PhD, Freund, Gregory G., MD, Woods, Jeffrey A., PhD, Cook, Marc D., PhD, Goldstein, Eric, MS, Fernhall, Bo, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood Coagulation - physiology
Body mass index
Cardiovascular
Cardiovascular disease
Case-Control Studies
Fibrinogen - metabolism
Firefighters
Fires
Hemostasis - physiology
Humans
Male
Obesity
Obesity - blood
Physical Exertion - physiology
Plasminogen Activator Inhibitor 1 - blood
Platelet Function Tests
Stress, Physiological - physiology
Stress, Psychological - blood
Tissue Plasminogen Activator - blood
Weight control
Young Adult
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Summary:The objective of this study was to evaluate the impact of obesity and firefighting activities on coagulation and fibrinolytic activity in relatively young, apparently healthy firefighters. Firefighters performed simulated firefighting activities for 18 minutes in a live-fire training structure. Blood samples were obtained at baseline, before firefighting, and within a few minutes of completing the activity. Nearly all markers of coagulation and fibrinolytic activity increased immediately after firefighting with an overall shift toward a procoagulatory profile. Obese firefighters exhibited lower levels of tissue plasminogen activator activity (0.98 vs 0.63 IU/ml) and higher levels of plasminogen activator inhibitor-1 activity (2.2 vs 4.5 ng/ml) at baseline compared with normal-weight firefighters, suggesting that fibrinolytic activity was lower in obese firefighters. There were few interactions between body mass index and firefighting activity, thus our findings suggest that obese firefighters did not exhibit a greater procoagulatory response to live firefighting compared with normal-weight firefighters. Acute live firefighting produced increases in both fibrinolytic and coagulatory responses; although obesity was associated with a reduced fibrinolytic profile at baseline, the changes produced by acute firefighting were similar in obese and nonobese firefighters.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2014.08.046