Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine

Highlights • GI.1/GII.4 bivalent Norovirus-like particle vaccine elicited B cell plasmablasts in peripheral blood. • High frequencies of VLP-specific antibody secreting cells were present in peripheral blood. • Plasmablasts exhibited a strongly mucosal homing phenotype and high proportions of IgA se...

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Bibliographic Details
Published in:Vaccine 2015-01, Vol.33 (4), p.568-576
Main Authors: Sundararajan, Aarthi, Sangster, Mark Y, Frey, Sharon, Atmar, Robert L, Chen, Wilbur H, Ferreira, Jennifer, Bargatze, Robert, Mendelman, Paul M, Treanor, John J, Topham, David J
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adolescent
Adult
Allergy and Immunology
Animals
Antibodies, Viral - immunology
Antibody
B cell
B-Lymphocytes - immunology
Colleges & universities
Double-Blind Method
Enzymes
Female
Flow cytometry
Genotypes
Human papillomavirus
Humans
Immunity, Mucosal
Immunization
Immunization - methods
Immunoassay
Immunogenicity
Immunoglobulin A - immunology
Immunoglobulin G - immunology
Injections, Intramuscular
Laboratories
Male
Middle Aged
Mucosal
Norovirus
Norovirus - immunology
Phosphatase
Placebos - administration & dosage
Software
Treatment Outcome
Vaccine
Vaccines
Vaccines, Virus-Like Particle - administration & dosage
Vaccines, Virus-Like Particle - genetics
Vaccines, Virus-Like Particle - immunology
Viral Vaccines - administration & dosage
Viral Vaccines - genetics
Viral Vaccines - immunology
Young Adult
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Summary:Highlights • GI.1/GII.4 bivalent Norovirus-like particle vaccine elicited B cell plasmablasts in peripheral blood. • High frequencies of VLP-specific antibody secreting cells were present in peripheral blood. • Plasmablasts exhibited a strongly mucosal homing phenotype and high proportions of IgA secreting cells. • Results are consistent with recall of pre-existing cellular immune memory.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.09.073