The importance of association between angiotensin-converting enzyme (ACE) Gene I/D polymorphism and diabetic peripheral neuropathy

• Published in: Gene 2013-11, Vol.530 (2), p.253-256
• Main Authors: Inanir, Ahmet, Basol, Nursah, Karakus, Nevin, Yigit, Serbulent
• Format: Article
• Language: English
• Subjects: Aged; Alleles; Amino Acid Substitution; Angiotensin-converting enzyme; Aspartic Acid - genetics; Case-Control Studies; diabetic complications; Diabetic Neuropathies - complications; Diabetic Neuropathies - genetics; Diabetic Neuropathies - pathology; Diabetic peripheral neuropathy; DNA; Female; Gene Frequency; Gene Polymorphism; Genetic Predisposition to Disease; Heterozygote; homozygosity; Homozygote; Humans; hypertension; Hypertension - complications; Hypertension - genetics; Hypertension - pathology; Isoleucine - genetics; Male; Middle Aged; patients; peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - genetics; peripheral nervous system diseases; polymerase chain reaction; Polymorphism, Genetic; quality of life
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2013.07.051

Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus (DM) due to decreasing quality of life. In the present study, it is aimed to evaluate angiotensin-converting enzyme (ACE) Gene I/D polymorphism in Turkish population. Two hundred and thirty-five DPN patients and two hundred and eighty-one controls were enrolled in this study. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) analyses for the ACE gene I/D polymorphism. Baseline characteristics of the DPN patients according to ACE genotypes were similar, except for history of hypertension. The frequency of II genotype was significantly higher in patients with positive history of hypertension than the patients with negative history of hypertension (p=0.013). DD genotype of I/D polymorphism was found to be a susceptibility factor for DPN in homozygous form (p=0.032). According to allele frequencies, D allele of I/D polymorphism was found to be a susceptibility factor for DPN (p=0.031). ACE gene I/D polymorphism may research in DM patients to determine genetic predisposition for DPN. It can be useful for taking early measures and avoiding DPN in a Turkish population. •DPN is the most common form of diabetic neuropathy.•ACE has important functions on neuroendocrine metabolism.•DD genotype was found to be a susceptibility factor for DPN.