The relationship between five widely-evaluated variants in CDKN2A/B and CDKAL1 genes and the risk of type 2 diabetes: A meta-analysis

The genes encoding two cyclin-dependent kinases-inhibitor-2A/B (CDKN2A/B) and 5 regulatory subunit-associated protein-like 1 (CDKAL1) have been investigated extensively in associations with type 2 diabetes; the results, however, are often irreproducible. We therefore sought to evaluate these associa...

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Bibliographic Details
Published in:Gene 2013-12, Vol.531 (2), p.435-443
Main Authors: Peng, Feng, Hu, Dan, Gu, Chaohao, Li, Xiaobo, Li, Yuqiong, Jia, Nan, Chu, Shaoli, Lin, Jinxiu, Niu, Wenquan
Format: Article
Language:English
Subjects:
alleles
Asians
Case-Control Studies
CDKAL1
CDKN2A/B
Cyclin-Dependent Kinase 5 - genetics
Cyclin-Dependent Kinase Inhibitor p15 - genetics
Cyclin-Dependent Kinase Inhibitor p16 - genetics
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - genetics
Female
gender
Gene
Genetic Predisposition to Disease
Humans
Male
Meta-analysis
noninsulin-dependent diabetes mellitus
odds ratio
patients
Polymorphism, Single Nucleotide - physiology
Retrospective Studies
risk
risk estimate
Risk Factors
tRNA Methyltransferases
Type 2 diabetes
Variant
Whites
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Summary:The genes encoding two cyclin-dependent kinases-inhibitor-2A/B (CDKN2A/B) and 5 regulatory subunit-associated protein-like 1 (CDKAL1) have been investigated extensively in associations with type 2 diabetes; the results, however, are often irreproducible. We therefore sought to evaluate these associations by performing a meta-analysis on five widely-evaluated variants from the two genes. There were 38 studies (patients/controls: 51,940/52,234) for rs10811661, 16 studies (20,029/24,419) for rs564398 in CDKN2A/B gene, and 27 studies (28,383/47,635) for rs7756992, 26 studies (28,816/31,713) for rs7754840, 21 studies (29,260/38,400) for rs10946398 in CDKAL1 gene. Overall risk estimates for type 2 diabetes conferred by rs10811661-T, rs564398-A, rs7754840-C, rs7756992-G, and rs10946398-C alleles were 1.17 (95% CI: 1.10–1.23; P
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2013.08.075