Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: Mitoprotection against Ca2+ -induced mitochondrial impairment

Highlights • JM-20 is a strong antioxidant in brain mitochondria. • JM-20 did not directly react with H2 O2 or O2•− , but prevented their formation. • JM-20 has a strong electron affinity and low redox potential similar to that of O2. • JM-20 protected brain mitochondria from Ca2+ -induced impairmen...

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Bibliographic Details
Published in:Brain research bulletin 2014-10, Vol.109, p.68-76
Main Authors: Nuñez-Figueredo, Yanier, Pardo-Andreu, Gilberto L, Ramírez-Sánchez, Jeney, Delgado-Hernández, René, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Naal, Zeki, Muller, Alexandre Pastoris, Portela, Luis Valmor, Souza, Diogo O
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Antioxidant
Antioxidants - pharmacology
Benzodiazepines - pharmacology
Brain ischemia
Calcium - toxicity
Catalase - pharmacology
Cytochromes c - metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors - pharmacology
JM-20
Male
Membrane Potential, Mitochondrial - drug effects
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Neurology
Neuroprotector
Niacin - analogs & derivatives
Niacin - pharmacology
Oligomycins - pharmacology
Oxygen - metabolism
Prosencephalon - ultrastructure
Rats
Rats, Wistar
Reactive Oxygen Species - metabolism
Superoxides - metabolism
Synaptosomes
Synaptosomes - drug effects
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Summary:Highlights • JM-20 is a strong antioxidant in brain mitochondria. • JM-20 did not directly react with H2 O2 or O2•− , but prevented their formation. • JM-20 has a strong electron affinity and low redox potential similar to that of O2. • JM-20 protected brain mitochondria from Ca2+ -induced impairment. • JM-20 inhibited Ca2+ influx into mitochondria.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2014.10.001