Evaluation of glutathione S-transferase genetic variants affecting type 2 diabetes susceptibility: A meta-analysis

Genetic polymorphisms of glutathione S-transferases (GSTs) and type 2 diabetes mellitus (T2DM) risk have been widely studied, however, the results were somewhat conflicting. To evaluate the association of GSTs (GSTM1, GSTT1 and GSTP1) gene polymorphisms with T2DM, a meta-analysis was performed befor...

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Bibliographic Details
Published in:Gene 2013-11, Vol.530 (2), p.301-308
Main Authors: Tang, Song-tao, Wang, Chang-jiang, Tang, Hai-qin, Zhang, Qiu, Wang, Yuan
Format: Article
Language:English
Subjects:
Adult
Aged
Asians
Case-Control Studies
Diabetes
Diabetes Mellitus, Type 2 - genetics
Female
genes
genetic polymorphism
Genetic Predisposition to Disease
Genotype
Glutathione S-transferase
Glutathione S-Transferase pi - genetics
glutathione transferase
Glutathione Transferase - genetics
Humans
Male
Meta-analysis
Middle Aged
noninsulin-dependent diabetes mellitus
Polymorphism, Genetic
Risk
Susceptibility
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Summary:Genetic polymorphisms of glutathione S-transferases (GSTs) and type 2 diabetes mellitus (T2DM) risk have been widely studied, however, the results were somewhat conflicting. To evaluate the association of GSTs (GSTM1, GSTT1 and GSTP1) gene polymorphisms with T2DM, a meta-analysis was performed before October, 2012. ORs were pooled according to random-effects model. There were a total of 1354/1666 (n=9) cases/controls (studies) for GSTM1, 1271/1470 (n=8) for GSTT1, and 1205/1250 (n=7) for GSTM1. There were significant associations between GSTM1 polymorphism, GSTT1 polymorphism and T2DM in the contrast of present genotype vs. null genotype, with pooled OR=1.99 (95%CI=1.46–2.71) and OR=1.61 (95%CI=1.19–2.17), respectively. Yet no significant association of GSTP1 polymorphism and T2DM was showed. When stratified by ethnicity, the significant associations were also existed in Asians for GSTM1 and GSTT1, but not GSTP1. No publication bias but some extent of heterogeneity was observed. Finally, the accumulated evidence proved the obvious associations of GSTM1 and GSTT1 polymorphisms with an increased risk of T2DM. •We haven’t found the similar research until now.•We quantitatively summarized 10 studies by means of meta-analysis.•The evidence of this paper is sufficient and strong.•The association of GSTs polymorphisms and T2DM has been clarified.•We have discussed three most important gene polymorphisms.
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2013.08.043