Mitochondrial dysfunction in schizophrenia: an evolutionary perspective

Schizophrenia (SCZ) is a severe psychiatric illness with a lifetime prevalence of 0.4 %. A disturbance of energy metabolism has been suggested as part of the etiopathogenesis of the disorder. Several lines of evidence have proposed a connection between etiopathogenesis of SCZ and human brain evoluti...

Full description

Saved in:
Bibliographic Details
Published in:Human genetics 2015-01, Vol.134 (1), p.13-21
Main Authors: Gonçalves, Vanessa F., Andreazza, Ana C., Kennedy, James L.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Brain
Energy
Evolution
Gene Function
Glucose
Human Genetics
Humans
Mental disorders
Mental health
Metabolic Diseases
Metabolism
Mitochondria
Mitochondria - pathology
Mitochondrial Diseases - complications
Mitochondrial DNA
Molecular Medicine
Nervous system
Neurophysiology
Pathophysiology
Phosphorylation
Physiological aspects
Review Paper
Schizophrenia
Schizophrenia - etiology
Schizophrenia - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Schizophrenia (SCZ) is a severe psychiatric illness with a lifetime prevalence of 0.4 %. A disturbance of energy metabolism has been suggested as part of the etiopathogenesis of the disorder. Several lines of evidence have proposed a connection between etiopathogenesis of SCZ and human brain evolution, which was characterized by an increase in the energy requirement, demanding a co-evolution of the mitochondrial system. Mitochondria are key players in brain energy homeostasis and multiple lines of evidence suggest that the system is disrupted in SCZ. In this review, we will describe the current knowledge on pathways/system involved in the human brain evolution as well as the main theories regarding the evolutionary origin of SCZ. We will furthermore discuss the role of mitochondria in the context of brain energy metabolism and its role in the etiopathogenesis of SCZ. Understanding SCZ in the context of human brain evolution opens a new perspective to elucidate pathophysiological mechanisms involved in the origin and/or portions of the complex symptomatology of this severe mental disorder.
ISSN:0340-6717
1432-1203
DOI:10.1007/s00439-014-1491-8