Arrest of progression of pre-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by low level laser phototherapy

Background and Objectives Using non‐invasive, high‐frequency ultrasonography (HF‐u/s), we showed that low‐level laser phototherapy (LLL) inhibits de‐novo formation of abdominal aortic aneurysms (AAA) in apolipoprotein‐E‐deficient (Apo‐E‐/‐) mice. The current study tests the effect of LLL on the prog...

Full description

Saved in:
Bibliographic Details
Published in:Lasers in surgery and medicine 2014-12, Vol.46 (10), p.781-790
Main Authors: Gavish, Lilach, Beeri, Ronen, Gilon, Dan, Rubinstein, Chen, Berlatzky, Yacov, Bulut, Atilla, Reissman, Petachia, Gavish, Leah Y., Gertz, S. David
Format: Article
Language:English
Subjects:
Abdomen
abdominal aortic aneurysm
aneurysm
Aneurysms
Angiotensin II
Animals
Aortic Aneurysm, Abdominal - etiology
Aortic Aneurysm, Abdominal - prevention & control
Aortic Aneurysm, Abdominal - radiotherapy
apolipoprotein-E-deficient mice
Apolipoproteins
Apolipoproteins E - deficiency
Disease Models, Animal
Lasers, Semiconductor - therapeutic use
Light therapy
low level laser (light) therapy (LLLT)
Low-Level Light Therapy
Mice
Mice, Inbred C57BL
photobiomodulation (PBM)
Rodents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Objectives Using non‐invasive, high‐frequency ultrasonography (HF‐u/s), we showed that low‐level laser phototherapy (LLL) inhibits de‐novo formation of abdominal aortic aneurysms (AAA) in apolipoprotein‐E‐deficient (Apo‐E‐/‐) mice. The current study tests the effect of LLL on the progression of pre‐induced AAA. Study Design/Material and Methods AAA was induced in Apo‐E‐/‐ mice (age16–20 weeks) by subcutaneous infusion of angiotensin‐II using osmotic minipumps (1000 ng/kg/minutes, 4 weeks). HF‐u/s (40 MHz, 0.01 mm resolution, Vevo‐770, VisualSonics) was used to measure the maximum cross‐sectional‐diameter (MCD) of the suprarenal abdominal aorta, the anterior wall displacement (AWD), and radial wall velocity (RWV). The aortas of mice that developed >35% dilatation at 2 weeks over baseline were exposed retroperitoneally and treated with LLL (780 nm, 2.2 J/cm2, 9 minutes) or sham‐operated. HF‐u/s was repeated at 4 weeks, the mice sacrificed by perfusion fixation, and the aortas excised for histopathology. Results Of all mice with >35% MCD expansion of the suprarenal aorta at 2 weeks, 7(58%) of 12 non‐treated, but only 1(7%) of 14 LLL, had increased MCD(> 1 SD) at 4 weeks (P 
ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.22306