Exercise Training Improves HR Responses and V times O2peak in Predialysis Kidney Patients

• Published in: Medicine and science in sports and exercise 2012-12, Vol.44 (12), p.2392-2399
• Main Authors: Headley, Samuel, Germain, Michael, Milch, Charles, Pescatello, Linda, Coughlin, Mary Ann, Nindl, Bradley C, Cornelius, Allen, Sullivan, Sheila, Gregory, Sara, Wood, Richard
• Format: Article
• Language: English
• ISSN: 0195-9131
• DOI: 10.1249/MSS.0b013e318268c70c

The current pilot and feasibility study was designed to examine the effect of 48 wk of moderate-intensity exercise training and dietary modification on kidney function and vascular parameters in chronic kidney disease (CKD) patients. Twenty-one stage 2-4 CKD patients (age, 18-70 yr) were randomly assigned to either the training group (TG, n = 10) or the usual care group (n = 11) for 48 wk. The TG received 48 wk of personal training (3 d times wk super(-1) for up to 55 min per session at 50%-60% V super( times )O sub(2peak)) and dietary counseling, whereas individuals in the usual care group received standard of care and were instructed not to start a structured exercise program while in the study. The 48-wk intervention led to a significant increase in V super( times )O sub(2peak), reductions in both resting and ambulatory HR, and increases in LDL cholesterol and in TG, but it had no effect on the rate of change of eGFR overtime.