Correlation between salivary Toll like receptor-2 concentration and early childhood caries

Early childhood caries (ECC) is a common health problem in developing countries. Basic knowledge about etiology and pathogenesis of ECC plays an important role in its prevention. To determine the relationship between salivary TLR-2 concentration and early childhood caries formation. Twenty-Eight chi...

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Bibliographic Details
Published in:Iranian journal of immunology 2014-09, Vol.11 (3), p.210-216
Main Authors: Malekafzali, Beheshteh, Sattari, Mandana, Keyvanfar, Sanaz
Format: Article
Language:English
Subjects:
Bacteria
Case-Control Studies
Child
Child, Preschool
Dental caries
Dental Caries - epidemiology
Dental Caries - etiology
Humans
Laboratories
Patients
Pediatrics
Preschool education
Public Health Surveillance
Saliva - metabolism
Studies
Toll-Like Receptor 2 - metabolism
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Summary:Early childhood caries (ECC) is a common health problem in developing countries. Basic knowledge about etiology and pathogenesis of ECC plays an important role in its prevention. To determine the relationship between salivary TLR-2 concentration and early childhood caries formation. Twenty-Eight children with ages ranging from 36 to 71 months (15 in ECC group and 13 in caries free group) were chosen based on inclusion criteria. Their saliva was aspirated in the volumes of 1-2 ml. Resampling was done for 8 subjects of ECC group 3 months after dental restoration. TLR-2 concentration was measured using ELISA. Mean concentrations of TLR-2 in ECC and caries free group were 2.12 and 1.42 ng/ml, respectively. The difference between concentrations was statistically significant (p=0.008). Three months after treatment in 8 ECC, the mean concentration of TLR-2 (0.925 ng/ml) significantly decreased compared to the original concentration in ECC (p
ISSN:1735-1383
1735-367X