Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea

• Published in: Inflammation research 2015-01, Vol.64 (1), p.21-29
• Main Authors: da Rosa, Darlan Pase, Forgiarini, Luiz Felipe, e Silva, Mariel Barbachan, Fiori, Cíntia Zappe, Andrade, Cristiano Feijó, Martinez, Dênis, Marroni, Norma Possa
• Format: Article
• Language: English
• Subjects: Acetylcysteine - pharmacology; Acetylcysteine - therapeutic use; Allergology; Animals; Antioxidants - pharmacology; Antioxidants - therapeutic use; Apoptosis - drug effects; Biomedical and Life Sciences; Biomedicine; Caspases - metabolism; Dermatology; Disease Models, Animal; Hypoxia - etiology; Hypoxia - metabolism; Hypoxia - pathology; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Immunology; Inflammation - metabolism; Inflammation - pathology; Inflammation - prevention & control; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; Melatonin - pharmacology; Melatonin - therapeutic use; Mice; Mice, Inbred BALB C; Neurology; NF-kappa B - metabolism; Nitric Oxide Synthase Type II - metabolism; Original Research Paper; Oxidative Stress - drug effects; Pharmacology/Toxicology; Rheumatology; Sleep Apnea Syndromes - complications; Tumor Necrosis Factor-alpha - metabolism; Vascular Endothelial Growth Factor A - metabolism
• ISSN: 1023-3830; 1420-908X
• DOI: 10.1007/s00011-014-0778-5

Background Sleep apnea causes intermittent hypoxia (IH). We aimed to investigate the proteins related to oxidative stress, inflammation and apoptosis in liver tissue subjected to IH as a simulation of sleep apnea in conjunction with the administration of either melatonin (MEL, 200 μL/kg) or N -acetylcysteine (NAC, 10 mg/kg). Methods Seventy-two adult male Balb-C mice were divided: simulation of IH (SIH), SIH + MEL, SIH + NAC, IH, IH + MEL and IH + NAC. The animals were subjected to simulations of sleep apnea for 8 h a day for 35 days. The data were analyzed with ANOVA and Tukey tests with the significance set at p