Blockade of Morphine-Induced Hindlimb Myoclonic Seizures in Mice by Ketamine

Morphine administration can lead to a variety of side-effects, including myoclonus. In an animal model, high morphine doses given intrathecally elicit hindlimb myoclonic seizures which are not influenced by traditional opioid receptor antagonists, such as naloxone. Ketamine prevents this seizure-lik...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1997-03, Vol.56 (3), p.423-425
Main Authors: Kolesnikov, Y, Jain, S, Wilson, R, Pasternak, G.W
Format: Article
Language:English
Subjects:
Amino Acids - pharmacology
Analgesics, Opioid - adverse effects
Analgesics, Opioid - antagonists & inhibitors
Animals
Biological and medical sciences
Disease Models, Animal
Dose-Response Relationship, Drug
Drug toxicity and drugs side effects treatment
Epilepsies, Myoclonic - chemically induced
Epilepsies, Myoclonic - drug therapy
Epilepsy
Excitatory Amino Acid Antagonists - pharmacology
Hindlimb
Ketamine - pharmacology
Male
Medical sciences
Mice
Mice, Inbred Strains
Morphine - adverse effects
Morphine - antagonists & inhibitors
Mu receptor
Myoclonus
Opioid receptor
Pharmacology. Drug treatments
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Stereoisomerism
Toxicity: nervous system and muscle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Morphine administration can lead to a variety of side-effects, including myoclonus. In an animal model, high morphine doses given intrathecally elicit hindlimb myoclonic seizures which are not influenced by traditional opioid receptor antagonists, such as naloxone. Ketamine prevents this seizure-like activity in a dose-dependent manner. The response is stereoselective, with S-ketamine far more potent than R-ketamine. A competitive NMDA antagonist, NPC17742, also prevents the seizures, although less potently than ketamine. Dextromethorphan has limited activity in this model, while haloperidol and pentothal are without any effect.
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(96)00221-3