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Secretory phospholipase A sub(2) is the principal bactericide for staphylococci and other gram-positive bacteria in human tears

We examined human tears for molecules that killed gram-positive bacteria. The principal mediator of bactericidal activity against staphylococci proved to be a calcium-dependent enzyme, secretory phospholipase A sub(2). Whereas the concentration of secretory phospholipase A sub(2) in the normal tear...

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Bibliographic Details
Published in:Infection and immunity 1998-06, Vol.66 (6), p.2791-2797
Main Authors: Qu, Xiao-Dan, Lehrer, R I
Format: Article
Language:English
Online Access:Get full text
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Summary:We examined human tears for molecules that killed gram-positive bacteria. The principal mediator of bactericidal activity against staphylococci proved to be a calcium-dependent enzyme, secretory phospholipase A sub(2). Whereas the concentration of secretory phospholipase A sub(2) in the normal tear film exceeded 30 mu g/ml, only 1.1 ng (
ISSN:0019-9567