Biotransformation of isoquinoline, phenanthridine, phthalazine, quinazoline, and quinoxaline by Streptomyces viridosporus

Streptomyces viridosporus T7A (ATCC39115), during growth in tryptone/yeast extract broth, cometabolized five heterocyclic nitrogen-containing compounds. The metabolites produced from the azaarenes were identified by high-performance liquid chromatography, UV/visible absorption spectroscopy, andmass...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 1998-04, Vol.49 (4), p.445-449
Main Authors: SUTHERLAND, J. B, FREEMAN, J. P, WILLIAMS, A. J
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Biological and medical sciences
Biology of microorganisms of confirmed or potential industrial interest
Biotechnology
Biotransformation
Chromatography
Fundamental and applied biological sciences. Psychology
Liquid chromatography
Metabolites
Mission oriented research
Physiology and metabolism
Spectrometry
Yeasts
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Summary:Streptomyces viridosporus T7A (ATCC39115), during growth in tryptone/yeast extract broth, cometabolized five heterocyclic nitrogen-containing compounds. The metabolites produced from the azaarenes were identified by high-performance liquid chromatography, UV/visible absorption spectroscopy, andmass spectrometry. Isoquinoline was transformed to 1(2H)-isoquinolinone (14%), phenanthridine to 6(5H)-phenanthridinone (25%), phthalazine to 1(2H)-phthalazinone (46%), quinazoline to 2,4(1H,3H)-quinazolinedione (4%), and quinoxaline to 2(1H)-quinoxalinone (8%) and 1-methyl-2(1H)-quinoxalinone (12%).[PUBLICATION ABSTRACT]
ISSN:0175-7598
1432-0614
DOI:10.1007/s002530051196