Economic comparison of calcium fumarate and sodium fumarate production by Rhizopus arrhizus

The economics of using Na sub(2)CO sub(3) rather than CaCO sub(3) as the neutralizing agent in fumaric acid production by Rhizopus arrhizus) is investigated and compared with the benzene route. Because sodium fumarate, unlike calcium fumarate, is soluble, downstream processing is simplified by requi...

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Bibliographic Details
Published in:Applied biochemistry and biotechnology 1990, Vol.24, p.663-677
Main Authors: Gangl, I.C. (Illinois Institute of Technology, Chicago, IL), Weigand, W.A, Keller, F.A
Format: Article
Language:English
Subjects:
ACIDE ORGANIQUE
ACIDOS ORGANICOS
ANALISIS ECONOMICO
ANALYSE ECONOMIQUE
Biological and medical sciences
BIOLOGICAL PRODUCTION
Biotechnology
CALCIUM CARBONATE
CARBONATE
CARBONATE DE CALCIUM
CARBONATES
CARBONATO DE CALCIO
CARBONATOS
ECONOMIC ANALYSIS
FERMENTACION
FERMENTATION
FUMARIC ACID
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
ORGANIC ACIDS
Other active biomolecules
Production of active biomolecules
RHIZOPUS
Rhizopus arrhizus
SODIO
SODIUM
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Summary:The economics of using Na sub(2)CO sub(3) rather than CaCO sub(3) as the neutralizing agent in fumaric acid production by Rhizopus arrhizus) is investigated and compared with the benzene route. Because sodium fumarate, unlike calcium fumarate, is soluble, downstream processing is simplified by requiring less equipment and no heat, and also allows the reuse of cells. In spite of a fumaric acid productivity (g/L/h) 2.4 x lower than the CaCO sub(3) case, the Na sub(2)CO sub(3) alternative with cell reuse has a higher rate of return. However, with the current cost of petroleum, the selling price of fumaric acid from the benzene route is half as much as from an idealized Na sub(2)CO sub(3) fermentation.
ISSN:0273-2289
1559-0291