Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus

• Published in: Lupus 1998-01, Vol.7 (3), p.192-197
• Main Authors: Reifen, R, Blank, M, Afek, A, Kopilowiz, Y, Sklan, D, Gershwin, M E, German, B, Yoshida, S, Shoenfeld, Y
• Format: Article
• Language: English
• Subjects: Animals; Antibodies, Anti-Idiotypic; Antibodies, Anticardiolipin - blood; Antibodies, Anticardiolipin - drug effects; Antibodies, Antinuclear - blood; Antibodies, Antinuclear - drug effects; Body Weight - drug effects; Dietary Fats, Unsaturated - administration & dosage; Disease Models, Animal; DNA - immunology; Fatty Acids, Unsaturated - administration & dosage; Female; Linseed Oil - administration & dosage; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - chemically induced; Lupus Erythematosus, Systemic - immunology; Mice; Mice, Inbred BALB C; Minerals - blood
• ISSN: 0961-2033; 1477-0962
• DOI: 10.1191/096120398678919985

Objective: To examine the effect of diets with different polyunsaturated fatty acid contents, including linseed oil which contains 70% omega-3 fatty acids, on autoantibody production in idiotype induced mouse model of systemic lupus erythematosus (SLE). Methods: Five different fats were fed to mice with induced SLE and antibody titers to anti-DNA and anti-cardiolipin were determined and histological examination of kidneys were carried out. Results: SLE mice fed linseed oil showed lower titers of antibodies to DNA and to cardiolipin and less severe kidney damage than mice fed other diets, including fish oil. Conclusion: Use of linseed oil may attenuate the severity of SLE and this diet may be recommended for other auto-immune diseases as well.