A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes

Positron emission tomography (PET) and the dopamine (DA) metabolism tracer, [ 18 F] 6-fluoro- l- m-tyrosine (FMT) were used to evaluate the relationship between DA metabolism and the clinical stage of parkinsonism monkeys following either unilateral ICA MPTP infusion or unilateral ICA MPTP infusion...

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Bibliographic Details
Published in:Brain research 1998-09, Vol.805 (1), p.259-262
Main Authors: Eberling, Jamie L., Jagust, William J., Taylor, Scott, Bringas, John, Pivirotto, Phillip, VanBrocklin, Henry F., Bankiewicz, Krys S.
Format: Article
Language:English
Subjects:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Biological and medical sciences
Corpus Striatum - diagnostic imaging
Corpus Striatum - metabolism
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Models, Animal
Dopamine
Dopamine - metabolism
Dopamine Agents
FMT
Macaca mulatta
Medical sciences
Monkey
MPTP
Neurology
Parkinson Disease, Secondary - chemically induced
Parkinson Disease, Secondary - diagnostic imaging
Parkinson Disease, Secondary - physiopathology
Parkinson's disease
PET
Tomography, Emission-Computed
Tyrosine - analogs & derivatives
Tyrosine - metabolism
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Summary:Positron emission tomography (PET) and the dopamine (DA) metabolism tracer, [ 18 F] 6-fluoro- l- m-tyrosine (FMT) were used to evaluate the relationship between DA metabolism and the clinical stage of parkinsonism monkeys following either unilateral ICA MPTP infusion or unilateral ICA MPTP infusion and subsequent varying sequential systemic doses of MPTP. Clinical stage corresponded to PET measures of striatal DA metabolism, showing the usefulness of the overlesioned hemiparkinsonian monkey as a stable model of various stages of Parkinson's disease (PD).
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)00710-0