CD4 super(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions

We tested infectious human immunodeficiency virus type 1 (HIV-1) noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4 super(+) T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matc...

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Bibliographic Details
Published in:Journal of virology 1998-11, Vol.72 (11), p.9345-9347
Main Authors: Sylwester, A W, Grivel, J C, Fitzgerald, W, Rossio, J L, Lifson, J D, Margolis, L B
Format: Article
Language:English
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Summary:We tested infectious human immunodeficiency virus type 1 (HIV-1) noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4 super(+) T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120 mediated CD4 super(+) T-cell depletion, consistent with mechanisms requiring productive infection.
ISSN:0022-538X