Prospects for anxiolytic therapy: a reflection from different viewpoints

Benzodiazepines are the most commonly used and effective treatment of symptoms of anxiety, but they have drawbacks. The current challenge is to discover partial agonists that do not cause the adverse effects characteristic of benzodiazepines. The authors discuss the main drugs that are used in the t...

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Bibliographic Details
Published in:Drug discovery today 1998-10, Vol.3 (10), p.471-479
Main Authors: Millet, Bruno, Bayle, Franck-Jean, Olié, Jean-Pierre
Format: Article
Language:English
Subjects:
acute treatment
anxiety
anxiolytics
benzodiazepines
Biological and medical sciences
comorbidity
long-term treatment
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
placebo
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
serotonin
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Summary:Benzodiazepines are the most commonly used and effective treatment of symptoms of anxiety, but they have drawbacks. The current challenge is to discover partial agonists that do not cause the adverse effects characteristic of benzodiazepines. The authors discuss the main drugs that are used in the treatment of acute anxiety and some of the current or future alternatives and also highlight several problems that need to be resolved in the development of new anxiolytics.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(98)01239-2