Effects of lesion of the inferior olivary complex by 3-acetylpyridine on learning and memory in the rat

DA/HAN-strained male rats (pigmented rats) were submitted to two experimental tasks consisting of spatial learning (water-escape) and a passive avoidance conditioning. Both these tasks were performed by different animals. In order to destroy the inferior olivary complex, the animals were injected wi...

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Bibliographic Details
Published in:Journal of Comparative Physiology A 1992-12, Vol.171 (5), p.657-664
Main Authors: DAHHAOUI, M, STELZ, T, CASTON, J
Format: Article
Language:English
Subjects:
Anatomical correlates of behavior
Behavioral psychophysiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
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Summary:DA/HAN-strained male rats (pigmented rats) were submitted to two experimental tasks consisting of spatial learning (water-escape) and a passive avoidance conditioning. Both these tasks were performed by different animals. In order to destroy the inferior olivary complex, the animals were injected with 3-acetylpyridine either 9 days prior to the initial learning session or 24 h after completion of the learning task. They were retested (retrieval test) 10 days after the initial learning was achieved. Learning and retention were compared to those noted in control rats. Administration of 3-acetylpyridine before the initial learning did not prevent the spatial learning but the scores were greatly altered and the number of trials needed to reach the fixed learning criterion was much greater than in controls. However, 10 days later the animals had memorized their initial experience.
ISSN:0340-7594
1432-1351
DOI:10.1007/BF00194113