A DNA damage and stress inducible G protein- coupled receptor blocks cells in G sub(2)/M

Cell cycle progression is monitored by highly coordinated checkpoint machinery, which is activated to induce cell cycle arrest until defects like DNA damage are corrected. We have isolated an anti-proliferative cell cycle regulator named G2A (for G sub(2) accumulation), which is predominantly expres...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1998-10, Vol.95 (21), p.12334-12339
Main Authors: Weng, Z, Fluckiger, A, Nisitani, S, Wahl, MI, Le, L Q, Hunter, CA, Fernal, A A, Beau, MML, Witte, ON
Format: Article
Language:English
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Summary:Cell cycle progression is monitored by highly coordinated checkpoint machinery, which is activated to induce cell cycle arrest until defects like DNA damage are corrected. We have isolated an anti-proliferative cell cycle regulator named G2A (for G sub(2) accumulation), which is predominantly expressed in immature T and B lymphocyte progenitors and is a member of the seven membrane-spanning G protein-coupled receptor family. G2A overexpression attenuates the transformation potential of BCR-ABL and other oncogenes, and leads to accumulation of cells at G sub(2)/M independently of p53 and c-Abl. G2A can be induced in lymphocytes and to a lesser extent in nonlymphocyte cell lines or tissues by multiple stimuli including different classes of DNA-damaging agents and serves as a response to damage and cellular stimulation which functions to slow cell cycle progression.
ISSN:0027-8424