Genetic sequences and transcriptional regulation of the TNFA promoter: comparison of human and baboon

Tumor necrosis factor alpha (TNF alpha ) is a pluripotent cytokine which is important in host defense. TNF alpha is synthesized mainly by macrophages and lymphocytes in response to diverse stimuli, with bacterial lipopolysaccharide (LPS) being the most potent. Its biosynthesis is complex, and is tig...

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Bibliographic Details
Published in:Immunogenetics (New York) 1998-08, Vol.48 (3), p.202-207
Main Authors: Haudek, S B, Natmessnig, B E, Redl, H, Schlag, G, Giroir, B P
Format: Article
Language:English
Subjects:
Animals
Base Sequence
DNA - genetics
DNA Primers - genetics
Gene Expression Regulation - drug effects
Genes, Reporter
Humans
In Vitro Techniques
Lipopolysaccharides - pharmacology
Luciferases - genetics
Molecular Sequence Data
Papio - genetics
Papio - immunology
Promoter Regions, Genetic
Sequence Deletion
Sequence Homology, Nucleic Acid
Species Specificity
Tetradecanoylphorbol Acetate - pharmacology
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - genetics
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Summary:Tumor necrosis factor alpha (TNF alpha ) is a pluripotent cytokine which is important in host defense. TNF alpha is synthesized mainly by macrophages and lymphocytes in response to diverse stimuli, with bacterial lipopolysaccharide (LPS) being the most potent. Its biosynthesis is complex, and is tightly regulated at the transcriptional, translational, and post-translational levels. The human TNFA promoter contains an array of potential cis-acting regulatory elements; however, the role of each of these elements in the transcriptional activation of the human TNFA gene remains controversial and incomplete. Several groups have investigated the transcriptional activity, transcription factor binding elements, and polymorphisms of the human TNFA promoter. Taken together, these studies emphasize the importance of the region within the first 220 nucleotides upstream of the transcription start point (tsp).
ISSN:0093-7711
1432-1211
DOI:10.1007/s002510050424