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Pentachlorophenol-mediated mutagenic synergy with aromatic amines in Salmonella typhimurium
Pentachlorophenol (PCP), a widely used pesticide, enhanced the mutagenic potency of plant- or mammalian-activated 2-aminofluorene (2AF) as well as the direct-acting mutagen 2-acetoxyacetylaminofluorene (2AAAF) when assayed with specific Salmonella typhimurium strains. With 2AF the mutagenic synergy...
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Published in: | Mutation research. Genetic toxicology and environmental mutagenesis 1998-12, Vol.420 (1), p.115-124 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Pentachlorophenol (PCP), a widely used pesticide, enhanced the mutagenic potency of plant- or mammalian-activated 2-aminofluorene (2AF) as well as the direct-acting mutagen 2-acetoxyacetylaminofluorene (2AAAF) when assayed with specific
Salmonella typhimurium strains. With 2AF the mutagenic synergy was observed in strains YG1024, TA1538, and MP153. With 2AAAF the PCP-mediated synergy was observed with these strains and with strain TA98/1,8-DNP
6. The synergy was dependent upon the presence of an activated
N-acetoxy functional group and was only expressed at the
hisD3052 allele and not at the
hisG46 allele. Spectrophotometric analysis demonstrated that the rate of degradation of 2AAAF was reduced in the presence of PCP in phosphate buffer or with
S. typhimurium cytosol and thus PCP may be affecting the stability of the
N-acetoxy group of activated aromatic amines. |
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ISSN: | 1383-5718 1879-3592 |
DOI: | 10.1016/S1383-5718(98)00143-0 |