Determination of trifluoroacetic acid in rat milk samples by super(19)F-NMR spectroscopy and capillary gas chromatography

Hydrochlorofluorocarbon-123 (HCFC-123) is considered as a substitute for ozone-depleting halons and chlorinated fluorocarbons. Because of the expected widespread use of HCFC-123, it is necessary to study its toxicity. Important aspects of the toxicological evaluation are the identification and the q...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1998-04, Vol.16 (8), p.1381-1385
Main Authors: Preiss, A, Kruppa, J, Buschmann, J, Muegge, C
Format: Article
Language:English
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Summary:Hydrochlorofluorocarbon-123 (HCFC-123) is considered as a substitute for ozone-depleting halons and chlorinated fluorocarbons. Because of the expected widespread use of HCFC-123, it is necessary to study its toxicity. Important aspects of the toxicological evaluation are the identification and the quantification of the metabolites in different biological matrices. The major metabolite of HCFC-123 is trifluoroacetic acid (TFA) and several analytical methods (GC, GC-MS, NMR) have been developed to determine TFA in blood, urine and amniotic fluid. Furthermore, TFA, covalently bound to proteins, was identified in rat liver, kidney and other organs. For the investigation of reproductive toxic effects, it is important to determine metabolites in the matrix milk. Therefore, the aim of these investigations was to develop two independent analytical methods for the determination of TFA in rat milk and to compare the analytical results.
ISSN:0731-7085