Charge-mediated topical delivery of plasmid DNA with cationic lipid nanoparticles to the skin

Cationic lipid nanoparticles (cLNs) were modified to develop a gene delivery system for topical use via a dermal route. The cLNs were formulated using high pressure homogenization method and were composed of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), dioleoylphosphatidylethanolamine (DOPE), T...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-04, Vol.116, p.582-590
Main Authors: Jin, Su-Eon, Kim, Chong-Kook
Format: Article
Language:English
Subjects:
Animals
Cationic
Cations - chemistry
Cells, Cultured
Delivery systems
Deoxyribonucleic acid
DNA - chemistry
DNA - genetics
Gene Transfer Techniques
Genes
Homogenizing
Humans
Lipids
Lipids - chemistry
Mice
Nanoparticles
Nanoparticles - chemistry
NIH 3T3 Cells
Particle Size
Plasmid DNA
Plasmids - genetics
Skin - chemistry
Surface Properties
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Description
Summary:Cationic lipid nanoparticles (cLNs) were modified to develop a gene delivery system for topical use via a dermal route. The cLNs were formulated using high pressure homogenization method and were composed of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), dioleoylphosphatidylethanolamine (DOPE), Tween 20, and tricaprin as a solid core (1:1:1:1.67, w/w). The prepared cLNs were nanoscale-sized (
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2014.01.053